Investigation of Rota Virus Between Vaccinated and Unvaccinated Infants and Childern in Al-Najaf Governorate
Abstract
The study aims to investigate Rota virus in vaccinated and unvaccinated infants and childern in Al-Najaf governorate. To achieve this goal, collect 684 samples from Al-Zahraa Teaching Hospital for Maternity and Children in Al-Najaf governorate, through the period from 7 January 2024 A.D. to 1 December 2024 A.D. This study has revealed that the rota virus can be detected in stool samples from infants and children patients.The detection of Rota virus infections in samples has occurred by using immunochromatographic test (Rota virus rapid test kit). The Rota virus antigens has been detected in (463 out of 684) or (68%) in patients while remain as not found or negative result with virus (221out of 684) or 32%. The present study show the distribution of infants and children patients according to age. The age of patients with viral infections showed that the highest frequency was in age group A1 (23%) and the lowest frequency was in age group A4 and A5 (18%). All patients age group were selected in order to ensure comparable frequency distribution. In this study showed the symptomes that linked with rota virus infections in both vaccinated and unvaccinated cases, The first dose of rotarix vaccine show high percentage associated mild diarrhea (72%) and low percentage in other gastroentrites symptoms (12%). While the result with second dose of rotarix vaccine show high percentage associated other gastroentrites symptoms (87%) and low percentage in severe diarrhea (2%).
References
Aliabadi, N., Antoni, S., Mwenda, J. M., Weldegebriel, G., Biey, J. N., Cheikh, D., ... & Cohen, A. L. (2019). Global impact of rotavirus vaccine introduction on rotavirus hospitalisations among children under 5 years of age, 2008–16: findings from the Global Rotavirus Surveillance Network. The Lancet Global Health, 7(7), e893-e903. https://doi.org/10.1016/S2214-109X(19)30207-4
Anderson, E. J., & Weber, S. G. (2004). Rotavirus infection in adults. Lancet Infectious Diseases, 4(2), 91–99. https://doi.org/10.1016/s1473-3099(04)00928-4
Bern, C., Martines, J., de Zoysa, I., & Glass, R. I. (1992). The magnitude of the global problem of diarrhoeal disease: A ten-year update. Bulletin of the World Health Organization, 70(6), 705–714.
Brandt, C. D., Kim, H. W., Rodriguez, W. J., Arrobio, J. O., Jeffries, B. C., & Stallings, E. P. (1983). Pediatric viral gastroenteritis during eight years of study. Journal of Clinical Microbiology, 18(1), 71–78. https://doi.org/10.1128/jcm.18.1.71-78.1983
Burnett, E., Jonesteller, C. L., Tate, J. E., Yen, C., & Parashar, U. D. (2017). Global impact of rotavirus vaccination on childhood hospitalizations and mortality from diarrhea. Journal of Infectious Diseases, 215(11), 1666–1672. https://doi.org/10.1093/infdis/jix186
Cárcamo-Calvo, R., Muñoz, C., Buesa, J., Rodríguez-Díaz, J., & Gozalbo-Rovira, R. (2021). The rotavirus vaccine landscape, an update. Pathogens, 10(5), 520. https://doi.org/10.3390/pathogens10050520
Crawford, S. E., Ramani, S., Tate, J. E., Parashar, U. D., Svensson, L., Hagbom, M., ... & Estes, M. K. (2017). Rotavirus infection. Nature Reviews Disease Primers, 3(1), 1-16. https://doi.org/10.1038/nrdp.2017.83
Doro, R., Farkas, S. L., Martella, V., & Banyai, K. (2015). Zoonotic transmission of rotavirus: surveillance and control. Expert review of anti-infective therapy, 13(11), 1337-1350. https://doi.org/10.1586/14787210.2015.1089171
Giaquinto, C., Dominiak-Felden, G., Van Damme, P., Myint, T. T., Maldonado, Y. A., Spoulou, V., Mast, T. C., & Staat, M. A. (2011). Summary of effectiveness and impact of rotavirus vaccination with the oral pentavalent rotavirus vaccine: A systematic review of the experience in industrialized countries. Human Vaccines, 7(7), 734–748. https://doi.org/10.4161/hv.7.7.15511
Greenberg, H. B., & Estes, M. K. (2009). Rotaviruses: From pathogenesis to vaccination. Gastroenterology, 136(6), 1939–1951. https://doi.org/10.1053/j.gastro.2009.02.076
Greenberg, H. B., & Estes, M. K. (2013). Rotaviruses. In D. M. Knipe & P. M. Howley (Eds.), Fields virology (6th ed., pp. 1347–1401). Philadelphia: Lippincott Williams & Wilkins.
Hallowell, B. D., Chavers, T., Parashar, U., & Tate, J. E. (2022). Global estimates of rotavirus hospitalizations among children below 5 years in 2019 and current and projected impacts of rotavirus vaccination. Journal of the Pediatric Infectious Diseases Society, 11(4), 149–158. https://doi.org/10.1093/jpids/piab114
Hoffmann, T., Iturriza-Gómara, M., Faaborg-Andersen, J., Kraaer, C., Nielsen, C. P., & Gray, J. (2011). Prospective study of the burden of rotavirus gastroenteritis in Danish children and their families. European Journal of Pediatrics, 170(12), 1535–1539. https://doi.org/10.1007/s00431-011-1465-y
Janko, M. M., Joffe, J., Michael, D., Earl, L., Rosettie, K. L., Sparks, G. W., Albertson, S. B., Compton, K., Pedroza Velandia, P., Stafford, L., Zheng, P., Aravkin, A., Kyu, H. H., Murray, C. J., & Weaver, M. R. (2022). Cost-effectiveness of rotavirus vaccination in children under five years of age in 195 countries: A meta-regression analysis. Vaccine, 40(28), 3903–3917. https://doi.org/10.1016/j.vaccine.2022.05.042
Kargar, M., Jafarpour, T., & Najafi, A. (2012). Epidemiological survey of group A rotaviruses infection among children under 5 years with acute diarrhea. Zahedan Journal of Research in Medical Sciences, 14(8), 43–47.
Lei, J., Kusov, Y., & Hilgenfeld, R. (2018). Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein. Antiviral research, 149, 58-74. https://doi.org/10.1016/j.antiviral.2017.11.001
Leung, A. K., Kellner, J. D., & Davies, H. D. (2005). Rotavirus gastroenteritis. Advances in Therapy, 22(5), 476–487. https://doi.org/10.1007/BF02849868
Li, D. D., Yu, Q. L., Qi, S. X., Xie, Y., Zhang, Q., & Cui, S. X. (2010). [Study on the epidemiological of rotavirus diarrhea in Lulong in 2008-2009]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 24(1), 2–4.
Mafokwane, T., Djikeng, A., Nesengani, L. T., Dewar, J., & Mapholi, O. (2023). Gastrointestinal Infection in South African Children under the Age of 5 years: A Mini Review. Gastroenterology Research and Practice, 2023(1), 1906782. https://doi.org/10.1155/2023/1906782
Marinosci, A., Doit, C., Koehl, B., Belhacel, K., Mariani Kurkdjian, P., & Melki, I. (2016). Gastro-entérites nosocomiales à rotavirus: Étude rétrospective dans un service de pédiatrie générale. Archives de Pédiatrie, 23(11), 1118–1123. https://doi.org/10.1016/j.arcped.2016.07.006
Omatola, C. A., & Olaniran, A. O. (2022). Epidemiological significance of the occurrence and persistence of rotaviruses in water and sewage: a critical review and proposal for routine microbiological monitoring. Environmental Science: Processes & Impacts, 24(3), 380-399. https://doi.org/10.1039/D1EM00435B
Parashar, U. D., Hummelman, E. G., Bresee, J. S., Miller, M. A., & Glass, R. I. (2003). Global illness and deaths caused by rotavirus disease in children. Emerging infectious diseases, 9(5), 565. https://doi.org/10.3201/eid0905.020562
Patton, J. T. (2012). Rotavirus diversity and evolution in the post-vaccine world. Discovery Medicine, 13(68), 85–97.
Raini, S. K. (2015). Characterization of human rota virus group a serotypes causing gastroenteritis among children below five years and hiv-infected adults of viwandani slum in Nairobi, Kenya (Doctoral dissertation).
Shahidi, M., Mahmanzar, M., Mahdavi, B., Tokhanbigli, S., Sisakht, M. M., Moradi, B., ... & Ganjalikhani-Hakemi, M. (2022). SARS-CoV-2 NSP3, NSP4 and NSP6 mutations and Epistasis during the pandemic in the world: Evolutionary Trends and Natural Selections in Six Continents. MedRxiv preprint. https://doi.org/10.1101/2022.05.22.22275422
Stene, L. C., Honeyman, M. C., Hoffenberg, E. J., Haas, J. E., Sokol, R. J., Emery, L., ... & Rewers, M. (2006). Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Official journal of the American College of Gastroenterology| ACG, 101(10), 2333-2340. https://doi.org/10.1111/j.1572-0241.2006.00741.x
Sungkapalee, T., Puntukosit, P., Eunsuwan, O., Theamboonlers, A., Chongsrisawat, V., & Poovorawan, Y. (2006). Incidence and clinical manifestations of rotavirus infection among children with acute diarrhea admitted at Buri Ram Hospital, Thailand. Southeast Asian Journal of Tropical Medicine and Public Health, 37(6), 1125–1131.
Tate, J. E., Burton, A. H., Boschi-Pinto, C., Steele, A. D., Duque, J., & Parashar, U. D. (2012). 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: A systematic review and meta-analysis. Lancet Infectious Diseases, 12(2), 136–141. https://doi.org/10.1016/S1473-3099(11)70253-5
Thwaites, G., Fisher, M., Hemingway, C., Scott, G., Solomon, T., & Innes, J. (2009). British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. Journal of infection, 59(3), 167-187. https://doi.org/10.1016/j.jinf.2009.06.011
Uyar, C., & Mızrakçı, S. (2022). Global trends on rotavirus vaccine’s studies. Journal of Biotechnology and Strategic Health Research, 6(2), 146-153. https://doi.org/10.34084/bshr.1115592
Velázquez, F. R. (2009). Protective effects of natural rotavirus infection. Pediatric Infectious Disease Journal, 28(Suppl), S54–S56. https://doi.org/10.1097/inf.0b013e3181967c03
Wakuda, M., Ide, T., Sasaki, J., Komoto, S., Ishii, J., Sanekata, T., & Taniguchi, K. (2011). Porcine rotavirus closely related to novel group of human rotaviruses. Emerging Infectious Diseases, 17(8), 1491–1493. https://doi.org/10.3201/eid1708.101466
Wilck, M. B., Xu, Z. J., Stek, J. E., & Lee, A. W. (2021). Safety and immunogenicity of a fully-liquid DTaP-IPV-Hib-HepB vaccine (Vaxelis™) in premature infants. Human Vaccines & Immunotherapeutics, 17(1), 191-196. https://doi.org/10.1080/21645515.2020.1756668
World Health Organization. (2013). Rotavirus vaccines WHO position paper: Recommendations. Vaccine, 31(52), 6170–6171.
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