https://newinera.com/index.php/JournalLaLifesci/issue/feedJournal La Lifesci2026-04-15T10:13:26+07:00Andrew Setiawan Rusdiantoandrewsrusdianto@newinera.comOpen Journal Systems<p>International <strong>Journal La </strong><strong>Lifesci</strong> ISSN 2721-1207 (online) and ISSN 2721-1304 (Print) includes all the areas of research activities in all fields of Life Sciences such as Agricultural, Fisheries, Earth, Environmental Science, Botany, Zoology, Microbiology, Ecology, Ethnobiology, Biodiversity And Conservation Biology, Genetics, Biochemistry , Bioinformatics, Biophysics, Biostatistics, Cytobiology Developmental Biology, Entomology, Immunology , Molecular Biology, Virology, agronomy, plant and animal breeding, agricultural economics and rural sociology, Veterinary science, Ornithology, Primatology, Biogeography, Histology, Marine biology, Biochemical Sciences Aquaculture, Fishery Hydrography, Fishery Engineering, Aquatic ecosystem, Fish farming, Fisheries management, Fishery Biology, Wild fisheries, Ocean fisheries, and all fields related to life sciences.</p>https://newinera.com/index.php/JournalLaLifesci/article/view/3122Income Analiysis of Langsat Farmers2026-03-30T09:54:52+07:00Yerike Yerikeyerike.agr21@itbmpolman.ac.idJumriani Dambejumrianidambe@yahoo.comHamsah Hamsahhamsah@yahoo.com<p><em>The purpose of this study was to analyze the income of farmers who grow langsat in Sulewatang village and evaluate the feasibility of their agricultural activities using profit ratio (R/C) analysis. The primary data used were obtained from direct interviews with farmers who grow langsat, as well as secondary data collected from related institutions. The analysis method includes calculating total income (TR = P × Q), total costs (TC = FC + VC), and profit ratio (R/C = TR ÷ TC). The results showed that the average income of farmers who grow langsat reached 2,241,190 Indonesian rupiah, with a total production cost of 360,769 Indonesian rupiah. Thus, the farmer's net income was 1,880,421 Indonesian rupiah. The profitability coefficient (R/C) value of 6.21 indicates that R/C > 1, which means that langsat cultivation in Sulewatang village is profitable and feasible to be further developed.</em></p>2026-03-30T09:53:48+07:00Copyright (c) 2026 Journal La Lifescihttps://newinera.com/index.php/JournalLaLifesci/article/view/3136Alterations in VKORC1 Gene and Cardiac Enzymes in Acute and Chronic Congestive Heart Failure2026-04-15T10:13:26+07:00Dhuha Abdullah Abbasdhaabfd@gmail.com<p><em>disorder that activates compensatory mechanisms, including neurohormonal responses and circulatory adjustments, which initially preserve perfusion but later contribute to systemic and pulmonary congestion. This study examined the effect of acute and chronic CHF on VKORC1 gene overexpression and measured serum cardiac enzymes, namely troponin I (cTn I), creatine kinase MB (CK MB), lactate dehydrogenase (L LDH), and myoglobin (MYO MB), at each disease phase. The study included 40 CHF patients, consisting of 20 with acute CHF (ACHF) characterized by severe sudden cardiac symptoms and 20 with chronic CHF (CCHF) showing gradual progression, along with 20 healthy participants as a negative control group. Venous blood samples were collected for molecular analysis using quantitative PCR and for serological assessment of cardiac enzymes using quantitative ELISA. Statistical significance was determined using GraphPad Prism at p < 0.05. The results showed that, across all groups, the GG genotype frequency was significantly higher than GA and AA. However, allele frequency analysis of VKORC1 (-1639G>A) rs9923231 revealed significantly increased GA and AA frequencies in both ACHF and CCHF patients. Serologically, cTn I, CK MB, L LDH, and MYO MB levels were significantly elevated in both patient groups compared with controls. Between ACHF and CCHF, only CK MB was significantly higher in CCHF, while cTn I, L LDH, and MYO MB showed no significant difference. This appears to be the first Iraqi study linking VKORC1 with CHF phases, suggesting its potential as an indicator of both acute and chronic CHF, although further investigation is needed</em></p>2026-04-11T14:51:06+07:00Copyright (c) 2026 Journal La Lifesci