Literature Review: The Role of Ajwa Dates (Phoenix Dactylifera L.) as a Natural Phytoestrogen in Reducing Perimenopause Symptoms

  • Fitra Amalia Salsabila Students of the Medical Professional Program, Faculty of Medicine, Universitas Muslim Indonesia
  • Nasrudin Andi Mappaware Department of Obstetrics and Gynecology Faculty of Medicine, Universitas Muslim Indonesia
  • Haeriyanty Department of Obstetrics and Gynecology Faculty of Medicine, Universitas Muslim Indonesia
Keywords: Perimenopause, Ajwa Dates, Phytoestrogen

Abstract

Perimenopause is a transitional phase before menopause characterized by a decrease in estrogen levels and the appearance of symptoms such as hot flushes, sleep disturbances, and mood changes. One natural alternative to reduce these symptoms is the use of phytoestrogens, which are plant compounds that mimic estrogen hormones. Ajwa dates (Phoenix dactylifera L.) contain flavonoids, phenolics, saponins, and phytoestrogens that have the potential to help balance hormones and reduce perimenopausal symptoms. This study aims to examine the role of Ajwa dates as a natural phytoestrogen in alleviating perimenopausal symptoms. This study employed a literature review design with a narrative approach. Data were obtained from five relevant national and international journals, with inclusion criteria covering studies discussing the role of Ajwa dates as a natural phytoestrogen in reducing perimenopausal symptoms. The data sources were analyzed qualitatively to assess the relationships between variables and the conclusions of the studies. The review results indicate that consumption of Ajwa dates can increase Anti-Mullerian Hormone (AMH) and Follicle Stimulating Hormone (FSH) levels, improve the number of de Graaf follicles, and thicken the endometrium. In vitro studies also show that Ajwa date extracts have significant antioxidant and phytoestrogenic activities. These effects contribute to improved ovarian function and the reduction of clinical symptoms caused by estrogen deficiency in perimenopausal women. Ajwa dates play an important role as a natural phytoestrogen capable of reducing perimenopausal symptoms through mechanisms such as hormonal balance improvement, antioxidant activity, and ovarian function enhancement.

References

Abdelghffar, E. A., Obaid, W. A., Mohammedsaleh, Z. M., Ouchari, W., Eldahshan, O. A., & Sobeh, M. (2022). Ajwa dates (Phoenix dactylifera L.) attenuate cisplatin-induced nephrotoxicity in rats via augmenting Nrf2, modulating NADPH oxidase-4 and mitigating inflammatory/apoptotic mediators. Biomedicine & Pharmacotherapy, 156, 113836. https://doi.org/10.1016/j.biopha.2022.113836

Abdullah, D., Wahyuni, S., & Zainun, Z. (2025). Kurma Ajwa sebagai Terapi Hipertensi: Tinjauan Ilmiah. Journal of Public Health Science, 2(2), 148–153. https://doi.org/10.70248/jophs.v2i2.2253

Abouzeid, E. M., Afifi, A. H., Hussei, R. A., Salama, A. A., Youssef, F. S., El‐Ahmady, S. H., & Ammar, N. M. (2024). Phoenix dactylifera L.: An Overview of Phytochemical Constituents and Impact on Women’s Health. Chemistry & Biodiversity, 21(7), 1–11. https://doi.org/10.1002/cbdv.202400456

AlFaris, N. A., AlTamim, J. Z., AlMousa, L. A., Albarid, N. A., & AlGhamidi, F. A. (2023). Nutritional values, Nutraceutical properties, and health benefits of Arabian Date Palme fruit. Emirates Journal of Food and Agriculture, 35, 488-510.

Aljohani, A. K., Maghrabi, N. A., Alrehili, O. M., Alharbi, A. S., Alsihli, R. S., Alharthe, A. M., Albladi, R. S., Alosaimi, K. A., Albadrani, B. M., Miski, S. F., Elbadawy, H. M., Alrehaili, B. D., Abdelkarem, F. A., & Hussein, M. F. (2025). Ajwa Date Extract (Phoenix dactylifera L.). Saudi Medical Journal, 46(1), 26–35. https://doi.org/10.15537/smj.2025.46.1.20240780

Almatroodi, S. A., Khan, A. A., Aloliqi, A. A., Ali Syed, M., & Rahmani, A. H. (2022). Therapeutic potential of Ajwa dates (Phoenix dactylifera) extract in prevention of benzo (a) pyrene-induced lung injury through the modulation of oxidative stress, inflammation, and cell signalling molecules. Applied Sciences, 12(13), 6784. https://doi.org/10.3390/app12136784

Alyahya, S., Arif, M., Wasim, R., & Kushwaha, S. P. (2022). Phoenix dactylifera L.(Ajwa Dates): An energetic plant fruit with immense nutraceuticals value for strengthening the power of resistance. Journal of Pharmacognosy and Phytochemistry, 11(3), 151-162. https://doi.org/10.22271/phyto.2022.v11.i3b.14404

Anwar, S., Raut, R., Alsahli, M. A., Almatroudi, A., Alfheeaid, H., Alzahrani, F. M., ... & Rahmani, A. H. (2022). Role of Ajwa date fruit pulp and seed in the management of diseases through in vitro and in silico analysis. Biology, 11(1), 78. https://doi.org/10.3390/biology11010078

Bachtiar, R., Anas, R., & Prisdayani, R. (2023). Efektivitas Berkumur Ekstrak Kurma Ajwa (Phoenix Dactylifera L.) terhadap Penurunan Indeks Plak pada Mahasiswa Pengguna Ortodonti Cekat di FKG UMI Angkatan 2019-2021. Indonesian Journal of Public Health , 1(3), 207–211.

Begum, H. A., Musa, M. U. H. A. M. M. A. D., Khan, A. S. I. F., Rafiq, N. A. S. E. E. M., AF, M. H., & Moon, Y. S. (2024). Pharmacological evaluation of Phoenix dactylifera L., seed extracts revealed analgesic, anti-inflammatory and antispasmodic activities. Pak. J. Bot, 56(3), 1075-1084.

Duralde, E. R., Sobel, T. H., & Manson, J. E. (2023). Management of perimenopausal and menopausal symptoms. Bmj, 382. https://doi.org/10.1136/bmj-2022-072612

Fadhila, U. T., Royani, I., Murfat, Z., Mappaware, N. A., & Khalid, N. (2023). Pengaruh Konsumsi Kurma Ajwa (Phoenix Dactylifera) terhadap Kadar Hemoglobin Ibu Hamil Anemia. MAHESA : Malahayati Health Student Journal, 3(10), 3203–3217. https://doi.org/10.33024/mahesa.v3i10.11168

Fruitasari, F. (2024). Gejala Menopause pada Wanita Premenopause. Journal of Nursing Invention, 5(1), 14–23. https://doi.org/10.33859/jni.v5i1.507

Hamsah, M., Irwan, I., Mappaware, N. A., Zulfamidah, Z., Royani, I., & Bulango, N. (2024). Case Report: Effect of Ajwa Date Consumption on LDL Levels in Perimenopausal Women. Journal La Medihealtico, 5(3), 572–576. https://doi.org/10.37899/journallamedihealtico.v5i3.1371

Hassan, S. M. A., Aboonq, M. S., Albadawi, E. A., Aljehani, Y., Abdel-Latif, H. M., Mariah, R. A., ... & Elbastawisy, Y. M. (2023). The preventive and therapeutic effects of Ajwa date fruit extract against acute diclofenac toxicity-induced colopathy: an Experimental Study. Drug Design, Development and Therapy, 2601-2616. https://doi.org/10.2147/DDDT.S344247

Irfan, I., Abdullah, N., Mappaware, N. A., As’ad, S., & Syakri, S. (2025). Effectiveness of the nutritional content and bioactive compounds of Ajwa dates (Phoenix dactylifera L) against anti-mullerian hormone (AMH) levels: A review. Research Journal of Pharmacy and Technology, 18(1), 415-420. http://dx.doi.org/10.52711/0974-360X.2025.00064

Kalita, K., Raina, D., & Mall, P. (2024). The Basics of Perimenopause: Menopause and Pre-Menopause. In Utilizing AI Techniques for the Perimenopause to Menopause Transition (pp. 1-25). IGI Global.

Khodijah, S., Surmiasih, Palupi, R., & Kameliawati, F. (2025). Hubungan Perubahan Fisik dengan Kualitas Hidup Wanita Menopause di Desa Pekon Wates Timur Gadingrejo Tahun 2024. Health Research Journal of Indonesia, 3(3), 159–164. https://doi.org/10.63004/hrji.v3i3.583

Koser, H. N., Mubarak, R., Jaffar, H. M., Rizwan, B., Mubashar, H., Kousar, S., ... & Islam, Z. (2022). A Review on Nutritional Composition of Phoenix Dactylifera L. And Its Pharmacological Functions: Pharmacological Properties of Phoenix dactylifera L. Pakistan BioMedical Journal, 5-9.

Kurniawan, L. (2023). The effect of ajwa dates (Phoenix dactylifera L) consumption to anti-Mullerian hormone level of perimenopausal woman. Food Res, 7, 105-10. https://doi.org/10.26656/fr.2017.7(3).1004

Kusumasari, H. A. R., Desyanti, H. H., Qurniatillah, M. H., Ratnawati, R., Norahmawati, E., Nurseta, T., & Wahyuni, E. S. (2020). The Effect Of Ajwa Dates Fruit Extract on Follicle Stimulating Hormone (FSH), Graafian Follicle and Endometrial Thickness in Female Rats Exposed to Arsenic. Journal of Global Pharma Technology, 12(8), 122–130.

Lestari, N. C. A., & Zulhijriani, Z. (2025). Faktor yang Mempengaruhi Gangguan Fisik pada Ibu Premenopause. Jurnal Ilmiah Kebidanan Dan Kesehatan (JIBI), 3(1), 27–34. https://doi.org/10.36590/jibi.v3i1.1449

Mani, V., Arfeen, M., Dhaked, D. K., Mohammed, H. A., Amirthalingam, P., & Elsisi, H. A. (2023). Neuroprotective effect of methanolic Ajwa seed extract on lipopolysaccharide-induced memory dysfunction and neuroinflammation: In vivo, molecular docking and dynamics studies. Plants, 12(4), 934. https://doi.org/10.3390/plants12040934

Metwally, A. M., Salah El-Din, E. M., Abdel Raouf, E. R., Elsaied, A., Ashaat, E. A., Yousef, W., ... & Anwar, M. (2024). Ajwa Dates Reduce Oxidative Stress in Egyptian Children with Autism: A Six-Month Randomized Controlled Trial. Egyptian Journal of Chemistry, 67(12), 585-599. https://doi.org/10.21608/ejchem.2024.329150.10649

Mulyadi, F. E., Natzir, R., Mappaware, N. A., As’ad, S., Sinrang, A. W., & Kurniawan, L. B. (2023). The Effect of Ajwa Dates (Phoenix dactylifera L) Consumption to Anti-Mullerian Hormone Level of Perimenopausal Woman. Food Research, 7(3), 105–110. https://doi.org/10.26656/fr.2017.7(3).1004

Mustakim, S., Mappaware, N. A., Arfah, A. I., Said, H., & Zulfamidah, Z. (2024). Literature Review: Pengaruh Buah Kurma Ajwa (Phoenix Dactylifera L) terhadap Kadar Hormon Progesteron. Innovative: Journal Of Social Science Research, 4(1), 4862–4871. https://doi.org/10.31004/INNOVATIVE.V4I1.7679

Mutiara, M., Mappaware, N. A., Arfah, A. I., Wahid, S., & Dewi, A. S. (2024). Literature Review: Pengaruh Buah Kurma Ajwa (Phoenix Dactylifera L.) Terhadap Kadar Hormon Androgen. Innovative: Journal Of Social Science Research, 4(1), 5872–5882. https://doi.org/10.31004/INNOVATIVE.V4I1.7678

Namirah, U., Arsal, A. S. F., Rasfayanah, Kanang, I. L. D., & Nasruddin, H. (2022). Pengaruh Pemberian Kurma Ajwa Sebagai Antibakterial dan Imunomodulator terhadap Bakteri Salmonella Typhi. Fakumi Medical Journal: Jurnal Mahasiswa Kedokteran, 2(7), 442–449. https://doi.org/10.33096/fmj.v2i7.86

Poorvi, R., Sneha, G. A., & Nikitha, M. K. (2024). Difficulties in Extracting Symptoms During Perimenopause. In Utilizing AI Techniques for the Perimenopause to Menopause Transition (pp. 180-200). IGI Global.

Rahma, M., Mappaware, N. A., & Diana, A. (2024). Case Report: The Effect Of Ajwa Dates On Calcium Levels In Perimenopause Women. Jurnal EduHealth, 15(02), 1080-1086.

Rahma, M., Mappaware, N. A., Diana, A., Nulanda, M., Hamsah, M., & Surdam, Z. (2024). Case Report: The Effect of Ajwa Dates on Calcium Levels in Perimenopausal Women. Journal La Medihealtico, 5(2), 418-423.

Royani, I., Mappaware, N. A., Hamsah, M., Latief, S., & Syahril, E. (2022). Potensi Kurma Ajwa (Phoenix Dactilifera L.) bagi Kesehatan Reproduksi Wanita dalam Literatur Islam dan Penelitian Ilmiah Terkini: Literatur Review. UMI Medical Journal, 7(2), 152–165. https://doi.org/10.33096/umj.v7i2.222

Saegana, U., Lawelai, H., & Dema, H. (2023). Metode Penelitian Sub Rumpun Ilmu Politik (Teori & Referensi Berbasis Studi Kasus). PT. Sonpedia Publishing Indonesia.

Salhi, S., Rahim, A., Chentouf, M., Harrak, H., Bister, J. L., Hamidallah, N., & El Amiri, B. (2024). Reproductive enhancement through phytochemical characteristics and biological activities of date palm pollen: A comprehensive review on potential mechanism pathways. Metabolites, 14(3), 166. https://doi.org/10.3390/metabo14030166

Sangar, G. H. M., Mirazi, N., Roodbari, N. H., & Hossieni, A. (2024). Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate. World Journal of Traditional Chinese Medicine, 10(4), 476–484. https://doi.org/10.4103/wjtcm.wjtcm_65_24

Shivanandappa, T. B., Alotaibi, G., Chinnadhurai, M., Dachani, S. R., Ahmad, M. D., & Aldaajanii, K. A. (2023). Phoenix dactylifera (Ajwa Dates) alleviate LPS-induced sickness behaviour in rats by attenuating proinflammatory cytokines and oxidative stress in the brain. International Journal of Molecular Sciences, 24(13), 10413. https://doi.org/10.3390/ijms241310413

Siregar, R., Lestari, D. A., Anggini, P. P., Tanti, D., Septiani, A., & Arsih. (2025). Edukasi Kecemasan pada Wanita Perimenopause dalam Mengatasi Menopause di RT 002 Desa Pasir Gombong. PROFICIO, 6(2), 832–839. https://doi.org/10.36728/jpf.v6i2.5135

Published
2026-02-06
How to Cite
Salsabila, F. A., Mappaware, N. A., & Haeriyanty, H. (2026). Literature Review: The Role of Ajwa Dates (Phoenix Dactylifera L.) as a Natural Phytoestrogen in Reducing Perimenopause Symptoms. Journal La Medihealtico, 7(1), 185-194. Retrieved from https://newinera.com/index.php/JournalLaMedihealtico/article/view/3034