Pulmonary TB Relapse Case Confirmed Bacteriologically with Cor Pulmonale Chronic Disease
Abstract
Tuberculosis is a chronic infectious disease prevalent in Indonesia caused by Mycobacterium tuberculosis. It primarily affects the lungs but can also invade other organs. It is essential to gather information on the patient's medical history, close contact with TB patients, environmental conditions, and occupation as a healthcare worker to assess the risk of infection transmission. Pulmonary TB can potentially relapse and lead to post-tuberculosis chronic lung disease, which can negatively impact the patient's prognosis and quality of life. If left untreated, it may also result in heart-lung disease, causing disruptions in cardiorespiratory function. Proper treatment is crucial to effectively manage TB and prevent complications.
References
Alhusban, Z., Alaaraj, M. M., Saimeh, A. R., Nassar, W., Awad, A., Ghanima, K., ... & Morra, M. E. (2025). Steroid‐Induced Cardiomyopathy: Insights From a Systematic Literature Review and a Case Report. Clinical Case Reports, 13(3), e70171. https://doi.org/10.1002/ccr3.70171
Allwood, B. W., Byrne, A., Meghji, J., Rachow, A., Van Der Zalm, M. M., & Schoch, O. D. (2021). Post-Tuberculosis Lung Disease: Clinical Review of an Under-Recognised Global Challenge. In Respiration (Vol. 100, Issue 8, pp. 751–763). S. Karger AG. https://doi.org/10.1159/000512531
Allwood, B. W., Van Der Zalm, M. M., Amaral, A. F. S., Byrne, A., Datta, S., Egere, U., Evans, C. A., Evans, D., Gray, D. M., Hoddinott, G., Ivanova, O., Jones, R., Makanda, G., Marx, F. M., Meghji, J., Mpagama, S., Pasipanodya, J. G., Rachow, A., Schoeman, I., … Mortimer, K. (2020). Post-tuberculosis lung health: Perspectives from the First International Symposium. International Journal of Tuberculosis and Lung Disease, 24(8), 820–828. https://doi.org/10.5588/ijtld.20.0067
Allwood, B., van der Zalm, M., Makanda, G., Mortimer, K., Andre F.S., A., Uzochukwu, E., Denise, E., Diane, G., Graeme, H., Olena, I., Rupert, J., Florian M., M., Jamilah, M., Stellah, M., Sanne, van K., Andrea, R., Ingrid, S., Cari, S., Dalene, von D., … Robert, W. (2019). The long shadow post-tuberculosis. In The Lancet Infectious Diseases (Vol. 19, Issue 11, pp. 1170–1171). Lancet Publishing Group. https://doi.org/10.1016/S1473-3099(19)30564-X
Alves-Jr, J. L., Oleas, F. G., & Souza, R. (2017, October). Pulmonary hypertension: definition, classification, and diagnosis. In Seminars in Respiratory and Critical Care Medicine (Vol. 38, No. 05, pp. 561-570). Thieme Medical Publishers. https://doi.org/10.1055/s-0037-1606577
Amin, M. S., & Hendriyanto, P. (2024). Science Midwifery Case report: Cor pulmonale in COPD. In Science Midwifery (Vol. 12, Issue 5). Online. www.midwifery.iocspublisher.orgJournalhomepage:www.midwifery.iocspublisher.org
Aprianti, S., Santoso, P., Barliana, M. I., & Pradipta, I. S. (2023). Article Review: The Treatment Problem And Adverse Drug Reactions In The Treatment Of Multidrug-Resistant Tuberculosis. Medical Sains: Jurnal Ilmiah Kefarmasian, 8(4), 1503-1524. http://dx.doi.org/10.37874/ms.v8i4.988
Arsyad, M. H., Syafina, I., Hapsah, H., & Hervina, H. (2024). Knowing and Understanding the Tuberculosis (Tb) Disease of the Lung (Literature Review). International Journal of Natural Science Studies and Development (IJOSS), 1(2), 56-85. http://dx.doi.org/10.55299/ijoss.v1i2.15
Burney, P., Jarvis, D., & Perez-Padilla, R. J. T. I. J. O. T. (2015). The global burden of chronic respiratory disease in adults. The International Journal of Tuberculosis and Lung Disease, 19(1), 10-20. https://doi.org/10.5588/ijtld.14.0446
Darmawan, M. A., Artawan, I. K., & Rini, N. M. (2025). Sindrom Obstruksi Pasca-Tuberkulosis (SOPT). Jurnal CDK, 52(1), 37–39.
David, M. N. V., & Shetty, M. (2024). Digoxin. In StatPearls [Internet]. StatPearls Publishing.
Davidson, G., Davidson, D. U., Okoye, O. K., Mensah, L. S., Ukaegbu, E. C., Agbor, D. B. A., ... & Uche, C. J. (2024). Overview of tuberculosis: causes, symptoms and risk factors. Asian J Res Infect Dis, 15(9), 8-19. https://doi.org/10.9734/ajrid/2024/v15i9370
Ekong, M., Monga, T. S., Daher, J. C., Sashank, M., Soltani, S. R., Nwangene, N. L., ... & Reza-Soltani, S. (2024). From the intensive care unit to recovery: managing post-intensive care syndrome in critically ill patients. Cureus, 16(5). https://doi.org/10.7759/cureus.61443
Fan, H., Wu, F., Liu, J., Zeng, W., Zheng, S., Tian, H., ... & Ran, P. (2021). Pulmonary tuberculosis as a risk factor for chronic obstructive pulmonary disease: a systematic review and meta-analysis. Annals of translational medicine, 9(5), 390. https://doi.org/10.21037/atm-20-4576
Gai, X., Allwood, B., & Sun, Y. (2023). Post-tuberculosis lung disease and chronic obstructive pulmonary disease. In Chinese Medical Journal (Vol. 136, Issue 16, pp. 1923–1928). Lippincott Williams and Wilkins. https://doi.org/10.1097/CM9.0000000000002771
Galvin, J., Tiberi, S., Akkerman, O., Kerstjens, H. A. M., Kunst, H., Kurhasani, X., ... & Migliori, G. B. (2022). Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review. Pulmonology, 28(4), 297-309. https://doi.org/10.1016/j.pulmoe.2022.01.016
Illini, O., Valipour, A., Gattinger, D., Petrovic, M., Fabikan, H., Hochmair, M. J., & Zwick, R. H. (2022). Effectiveness of outpatient pulmonary rehabilitation in patients with surgically resected lung cancer: a retrospective real-world analysis. Cancers, 14(14), 3479. https://doi.org/10.3390/cancers14143479
Jacobs, S. (2024). Characterising pathways that contribute to post-TB lung disease (Doctoral dissertation, Stellenbosch: Stellenbosch University).
Jeniffer, N. G. (2021). Factors associated with latent tuberculosis infection among HIV positive adults≥ 18 years in South Africa in 2016-2017: A cross-sectional study.
Kementerian Kesehatan Republik Indonesia. (2016). Permenkes RI Nomor 67 tahun 2016 tentang Penanggulangan Tuberkulosis. 163.
Kementerian Kesehatan Republik Indonesia. (2019). Keputusan Menteri Kesehatan Republik Indonesia No. HK.01.07/Menkes/755/2019 tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis. In Alternatif Penanggulangan Tuberkulosis (TBC): Wilayah Indonesia di Luar Sumatra dan Jawa-Bali. https://doi.org/10.14203/press.319
Kementrian Kesehatan Republik Indonesia. (2022). Dashboard PPM – TB Indonesia.
Khandelwal, D. R., Vagha, J. D., Meshram, R. J., & Patel, A. (2024). A Comprehensive Review on Unveiling the Journey of Digoxin: Past, Present, and Future Perspectives. Cureus. https://doi.org/10.7759/cureus.56755
Mandoli, G. E., Sciaccaluga, C., Bandera, F., Cameli, P., Esposito, R., D’Andrea, A., Evola, V., Sorrentino, R., Malagoli, A., Sisti, N., Nistor, D., Santoro, C., Bargagli, E., Mondillo, S., Galderisi, M., & Cameli, M. (2021). Cor pulmonale: the role of traditional and advanced echocardiography in the acute and chronic settings. In Heart Failure Reviews (Vol. 26, Issue 2, pp. 263–275). Springer. https://doi.org/10.1007/s10741-020-10014-4
Menzies, N. A., Quaife, M., Allwood, B. W., Byrne, A. L., Coussens, A. K., Harries, A. D., ... & Cohen, T. (2021). Lifetime burden of disease due to incident tuberculosis: a global reappraisal including post-tuberculosis sequelae. The Lancet Global Health, 9(12), e1679-e1687. https://doi.org/10.1016/s2214-109x(21)00367-3
Montani, D., Günther, S., Dorfmüller, P., Perros, F., Girerd, B., Garcia, G., ... & Sitbon, O. (2013). Pulmonary arterial hypertension. Orphanet journal of rare diseases, 8, 1-28. https://doi.org/10.1186/1750-1172-8-97
Mustofa, S., Megantoro, G. K., Gozali, A., Saputra, T. T., & Sanjaya, R. P. (2023). Sindrom Obstruksi Pasca Tuberkulosis Dengan Luluh Lobus: Laporan Kasus. Jurnal Ilmu Kedokteran Dan Kesehatan, 10(7), 2426–2430. https://doi.org/10.33024/jikk.v10i7.9698
Naeije, R., Richter, M. J., & Rubin, L. J. (2022). The physiological basis of pulmonary arterial hypertension. European Respiratory Journal, 59(6). https://doi.org/10.1183/13993003.02334-2021
Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M. V., McGroder, C., Stevens, J. S., ... & Wan, E. Y. (2021). Post-acute COVID-19 syndrome. Nature medicine, 27(4), 601-615. https://doi.org/10.1038/s41591-021-01283-z
NCBI Bookshelf. (2023). Cor pulmonale. In Garrison, Daniel M. Pendela, Venkata Satish Memon, Jawedulhadi.
Nematahe, M. N. (2023). Impact of pulmonary tuberculosis and HIV/AIDS co-infection in self-management among adult patients at the primary health care facilities in Bojanala District of North-West Province (Doctoral dissertation).
Nightingale, R., Carlin, F., Meghji, J., McMullen, K., Evans, D., Van Der Zalm, M. M., ... & Mortimer, K. (2023). Post-TB health and wellbeing. The International Journal of Tuberculosis and Lung Disease, 27(4), 248-283. https://doi.org/10.5588/ijtld.22.0514
Nopp, S., Moik, F., Klok, F. A., Gattinger, D., Petrovic, M., Vonbank, K., ... & Zwick, R. H. (2022). Outpatient pulmonary rehabilitation in patients with long COVID improves exercise capacity, functional status, dyspnea, fatigue, and quality of life. Respiration, 101(6), 593-601. https://doi.org/10.1159/000522118
Ozoh, O. B., Ojo, O. O., Dania, M. G., Dede, S. K., Adegboyega, O. A., Irurhe, N. K., ... & Adeyeye, O. O. (2021). Impact of post-tuberculosis lung disease on health-related quality of life in patients from two tertiary hospitals in Lagos, Nigeria. African Journal of Thoracic and Critical Care Medicine, 27(2), 46-52. https://doi.org/10.7196/ajtccm.2021.v27i2.135
Panganiban-Corales, A. T., & Medina, M. F. (2011). Family resources study: Part 1: Family resources, family function and caregiver strain in childhood cancer. Asia Pacific Family Medicine, 10(1). https://doi.org/10.1186/1447-056X-10-14
Perhimpunan Dokter Paru Indonesia, K. K. B. T. (2021). TUBERKULOSIS: PEDOMAN DIAGNOSIS DAN PENATALAKSANAAN DI INDONESIA (Revisi 2).
Rachow, A., Ivanova, O., Wallis, R., Charalambous, S., Jani, I., Bhatt, N., Kampmann, B., Sutherland, J., Ntinginya, N. E., Evans, D., Lönnroth, K., Niemann, S., Schaible, U. E., Geldmacher, C., Sanne, I., Hoelscher, M., & Churchyard, G. (2019). TB sequel: Incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB - A study protocol. BMC Pulmonary Medicine, 19(1). https://doi.org/10.1186/s12890-018-0777-3
Teibo, T. K. A., Andrade, R. L. D. P., Rosa, R. J., de Abreu, P. D., Olayemi, O. A., Alves, Y. M., ... & Arcêncio, R. A. (2024). Barriers that interfere with access to tuberculosis diagnosis and treatment across countries globally: a systematic review. ACS Infectious Diseases, 10(8), 2600-2614. https://doi.org/10.1021/acsinfecdis.4c00466
Varona Porres, D., Persiva, O., Pallisa, E., & Andreu, J. (2017). Radiological findings of unilateral tuberculous lung destruction. Insights into Imaging, 8(2), 271–277. https://doi.org/10.1007/s13244-017-0547-4
Wang, J., Li, R., Chang, J., Wang, Y., Lai, Y., Dong, Y., & Che, G. (2023). Quality of life between home-based and outpatient pulmonary rehabilitation in patients after surgical resection for lung cancer: protocol for a prospective, single-blind, randomised controlled trial. BMJ open, 13(5), e067845. https://doi.org/10.1136/bmjopen-2022-067845
Yach, D., Hawkes, C., Gould, C. L., & Hofman, K. J. (2004). The global burden of chronic diseases: overcoming impediments to prevention and control. Jama, 291(21), 2616-2622. https://doi.org/10.1001/jama.291.21.2616
Yandhi, R., & Ahmad, Z. (2024). Management of Isoniazid Monoresistant Tuberculosis. Bioscientia Medicina: Journal of Biomedicine and Translational Research, 8(7), 4606-4612. https://doi.org/10.37275/bsm.v8i7.1029
Zondo, N. N. (2022). Environmental Factors Associated with Tuberculosis Incidence and Mortality in Tshwane District, Gauteng Province, South Africa. University of Johannesburg (South Africa).
Copyright (c) 2025 Journal La Medihealtico

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.