Relationship Between Eosinophil Levels and Histopathological Grading of Colorectal Carcinoma

  • Abdul Mubdi Department of Internal Medicine, Faculty of Medicine, Universitas Muslim Indonesia
  • Gadista Mayssi Muthma'innah Medical Profession Study Program Student, Faculty of Medicine, Universitas Muslim Indonesia
  • Syarifuddin Wahid Department of Anatomical Pathology, Faculty of Medicine, Universitas Muslim Indonesia
Keywords: Eosinophil Levels, Histopathological Grading, Colorectal Carcinoma

Abstract

Colorectal cancer (CRC) is a multifactorial disease and a leading cause of cancer-related mortality. CRC ranks as the second most common cancer globally and the third most frequently diagnosed malignancy worldwide. Several studies have suggested that elevated eosinophil levels in peripheral blood correlate with poor prognosis in colorectal cancer cases. This study aims to analyze the relationship between eosinophil levels and histopathological grading of colorectal carcinoma by evaluating peripheral blood eosinophil counts in correlation with CRC histopathology grading. This research employs a descriptive-correlational approach, utilizing univariate and bivariate analyses. The study findings indicate a significant correlation between eosinophil levels and histopathological grading of colorectal carcinoma at Wahidin Sudirohusodo General Hospital, Makassar.

References

Diny, N. L., Rose, N. R., & Čiháková, D. (2017). Eosinophils in autoimmune diseases. Frontiers in immunology, 8, 484. https://doi.org/10.3389/fimmu.2017.00484

Grisaru-Tal, S., Itan, M., Klion, A. D., & Munitz, A. (2020). A new dawn for eosinophils in the tumour microenvironment. Nature Reviews Cancer, 20(10), 594-607. https://doi.org/10.1038/s41568-020-0283-9

Handler, K., Raju, D., Gurtner, A., Dalessi, T., Brügger, M. D., Crepaz, D., ... & Arnold, I. C. (2024). Eosinophils restrict CRC metastasis by inhibiting pro-tumorigenic SPP1+ macrophage differentiation. bioRxiv, 2024-12. https://doi.org/10.1101/2024.12.13.628333

Harbaum, L., Pollheimer, M. J., Kornprat, P., Lindtner, R. A., Bokemeyer, C., & Langner, C. (2015). Peritumoral eosinophils predict recurrence in colorectal cancer. Modern Pathology, 28(3), 403-413. https://doi.org/10.1038/modpathol.2014.104

Kasprzak, A. (2021). The role of tumor microenvironment cells in colorectal cancer (CRC) cachexia. International journal of molecular sciences, 22(4), 1565. https://doi.org/10.3390/ijms22041565

Kovalszki, A., & Weller, P. F. (2016). Eosinophilia. Primary care, 43(4), 607. https://doi.org/10.1016/j.pop.2016.07.010

Loktionov, A. (2019). Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders. World journal of gastroenterology, 25(27), 3503. https://doi.org/10.3748/wjg.v25.i27.3503

Lopez-Perez, D., Prados-Lopez, B., Galvez, J., Leon, J., & Carazo, A. (2024). Eosinophils in colorectal cancer: emerging insights into anti-tumoral mechanisms and clinical implications. International Journal of Molecular Sciences, 25(11), 6098. https://doi.org/10.3390/ijms25116098

Ohkuma, R., Kubota, Y., Horiike, A., Ishiguro, T., Hirasawa, Y., Ariizumi, H., ... & Wada, S. (2021). The prognostic impact of eosinophils and the eosinophil-to-lymphocyte ratio on survival outcomes in stage II resectable pancreatic cancer. Pancreas, 50(2), 167-175. https://doi.org/10.1097/mpa.0000000000001731

Pretlow, T. P., Keith, E. F., Cryar, A. K., Bartolucci, A. A., Pitts, A. M., Pretlow, T. G., ... & Boohaker, E. A. (1983). Eosinophil infiltration of human colonic carcinomas as a prognostic indicator. Cancer research, 43(6), 2997-3000.

Prizment, A. E., Vierkant, R. A., Smyrk, T. C., Tillmans, L. S., Lee, J. J., Sriramarao, P., ... & Limburg, P. J. (2016). Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa Women's Health Study. Modern pathology, 29(5), 516-527. https://doi.org/10.1038/modpathol.2016.42

Ramadan, S., Saka, B., Yarikkaya, E., Bilici, A., & Oncel, M. (2020). The potential prognostic role of peritumoral eosinophils within whole tumor-associated inflammatory cells and stromal histological characteristics in colorectal cancer. Polish Journal of Pathology, 71(3), 207-220. https://doi.org/10.5114/pjp.2020.99787

Ramirez, G. A., Yacoub, M. R., Ripa, M., Mannina, D., Cariddi, A., Saporiti, N., ... & Dagna, L. (2018). Eosinophils from physiology to disease: a comprehensive review. BioMed research international, 2018(1), 9095275.

Reichman, H., Itan, M., Rozenberg, P., Yarmolovski, T., Brazowski, E., Varol, C., ... & Munitz, A. (2019). Activated eosinophils exert antitumorigenic activities in colorectal cancer. Cancer immunology research, 7(3), 388-400. https://doi.org/10.1158/2326-6066.cir-18-0494

Rimini, M., Franco, P., De Bari, B., Zampino, M. G., Vagge, S., Frassinetti, G. L., ... & Casadei-Gardini, A. (2021). The prognostic value of the new combined Hemo-Eosinophil Inflammation Index (HEI Index): A multicenter analysis of anal cancer patients treated with concurrent chemo-radiation. Cancers, 13(4), 671. https://doi.org/10.3390/cancers13040671

Rosenberg, H. F., Dyer, K. D., & Foster, P. S. (2013). Eosinophils: changing perspectives in health and disease. Nature Reviews Immunology, 13(1), 9-22. https://doi.org/10.1038/nri3341

Rosman, Y., Hornik-Lurie, T., Meir-Shafrir, K., Lachover-Roth, I., Cohen-Engler, A., Munitz, A., & Confino-Cohen, R. (2022). Changes in peripheral blood eosinophils may predict colorectal cancer–A retrospective study. World Allergy Organization Journal, 15(10), 100696. https://doi.org/10.1016/j.waojou.2022.100696

Saraiva, A. L., & Carneiro, F. (2018). New insights into the role of tissue eosinophils in the progression of colorectal cancer: a literature review. Acta medica portuguesa, 31(6), 329-337. https://doi.org/10.20344/amp.10112

Simon, S. C., Utikal, J., & Umansky, V. (2019). Opposing roles of eosinophils in cancer. Cancer Immunology, Immunotherapy, 68, 823-833. https://doi.org/10.1007/s00262-018-2255-4

Wechsler, M. E., Munitz, A., Ackerman, S. J., Drake, M. G., Jackson, D. J., Wardlaw, A. J., ... & Merkel, P. A. (2021, October). Eosinophils in health and disease: a state-of-the-art review. In Mayo clinic proceedings (Vol. 96, No. 10, pp. 2694-2707). Elsevier. https://doi.org/10.1016/j.mayocp.2021.04.025

Published
2025-04-22
How to Cite
Mubdi, A., Muthma’innah, G. M., & Wahid, S. (2025). Relationship Between Eosinophil Levels and Histopathological Grading of Colorectal Carcinoma . Journal La Medihealtico, 6(3), 579-584. https://doi.org/10.37899/journallamedihealtico.v6i3.2103