Clinical Outcomes of Diabetic Patients with and without Hypertension Vaccinated with the Sinovac Vaccine

Sofia  Ngarso; Diana Laila  Ramatillah; Hasniza Zaman Huri

doi:10.37899/journallamedihealtico.v5i4.1460

Sofia Ngarso Magister Ilmu Farmasi, Fakultas Farmasi Universitas 17 Agustus 1945, Jakarta
Diana Laila Ramatillah Magister Ilmu Farmasi, Fakultas Farmasi Universitas 17 Agustus 1945, Jakarta
Hasniza Zaman Huri Fakultas Farmasi, Universitas Malaya, Malaysia

DOI: https://doi.org/10.37899/journallamedihealtico.v5i4.1460

Keywords: Diabetes, Hypertension, Sinovac, Clinical-Outcome

Abstract

Diabetes and hypertension are the most common degenerative diseases found during the Covid-19 vaccination. Of the 1488 cases of patients exposed to the Covis-19 virus, 13.2% died with hypertension and 11.6% with diabetes. This study aims to evaluate the clinical outcomes of diabetic and diabetic patients with hypertension who have been vaccinated with the Sinovac vaccine. This study uses retrospective and prospective cohort methods for 5 months. Of the 300 patients, 56.3% were female patients with the majority of the ages coming from the 41 to 60 years old group (46.7%) and 47.6% from the >60 years age group. There was no significant association between the length of diagnosis of diabetic patients and diabetes with hypertension and clinical outcomes. There was an association between kidney failure and clinical outcomes with the death of 8 people (2.7%) in patients with stage 4 and 5 renal failure. There was no association between sociodemographics and clinical outcomes. In comorbidities with Diabetes Mellitus, 3.33% of patients die. From the results of the study, it is also known that patients diagnosed with the disease >10 years have a higher percentage of mortality compared to patients diagnosed <10 years.

References

Albadrani, M. S., Aljeelani, Y. O., Farsi, S. H., Aljohani, M. A., Qarh, A. A., Aljohani, A. S., Alharbi, A. A., Tobaiqi, M. A. A., Aljohani, A. M., & Alzaman, N. S. (2024). Effect of medication adherence on quality of life, activation measures, and health imagine in the elderly people: a cross-sectional study. BMC Geriatrics, 24.

Apristina, A., Nurinda, E., Kusumawardani, N., Yugistyowati, A., & Dwinta, E. (2023). Analisis Hubungan Tingkat Kepatuhan Penggunaan Obat terhadap Luaran Klinis Pasien PROLANIS Diabetes Melitus dengan Hipertensi di Puskesmas Minggir pada. Pharmaceutical Journal of Indonesia, 8(2), 149–155.

Arjita, I. P. D., Adnyana, I. G. A., Anulus, A., Saputra, I. P. B. A., & Diarti, M. W. (2023). Immunological Profile of Patients with Controlled and Uncontrolled Type 2 Diabetes Melitus in Mataram City, West Nusa Tenggara. Jurnal Info Kesehatan, 21(2), 184–191. https://doi.org/10.31965/infokes.vol21.iss2.933

Astuti, L. W., Saluza, I., Yulianti, E., & Dhamayanti, D. (2022). Feature Selection Menggunakan Binary Wheal Optimizaton Algorithm (BWOA) pada Klasifikasi Penyakit Diabetes. Jurnal Ilmiah Informatika Global, 13(1).

Boroumand, A. B., Forouhi, M., Karimi, F., Moghadam, A. S., Naeini, L. G., Kokabian, P., & Naderi, D. (2022). Immunogenicity of COVID-19 vaccines in patients with diabetes mellitus: A systematic review. Frontiers in Immunology, 13(August). https://doi.org/10.3389/fimmu.2022.940357

Dewi, R. E., Putra, S. E. D., Aditama, L., & Wijono, H. (2020). Pengaruh Edukasi Perubahan Gaya Hidup Sehat terhadap Clinical Outcome pada Pasien di Rumah Diabetes Universitas Surabaya. MPI (Media Pharmaceutica Indonesiana), 3(2), 105–114. https://doi.org/10.24123/mpi.v3i2.2982

Driyah, S., Lisyani, B. S., & Kusmiyati, D. K. (2019). Korelasi Kontrol Glikemik dengan HDL dan Small-Dense LDL pada Penderita Diabetes Melitus dengan Komplikasi Jantung Koroner di RSUP Dr. Kariadi Semarang, Jawa Tengah. Jurnal Biotek Medisiana Indonesia, 8(1), 67–75.

Ichsan, D. S., Hafid, F., Ramadhan, K., & Taqwin, T. (2021). Determinan Kesediaan Masyarakat menerima Vaksinasi Covid-19 di Sulawesi Tengah. Poltekita : Jurnal Ilmu Kesehatan, 15(1), 1–11. https://doi.org/10.33860/jik.v15i1.430

Jackson, S. L., Woodruff, R. C., Nagavedu, K., Fearrington, J., Rolka, D. B., Twentyman, E., Carton, T. W., Puro, J., Denson, J. L., Kappelman, M. D., Paranjape, A., Thacker, D., Weiner, M. G., Goodman, A. B., Lekiachvili, A., Boehmer, T. K., & Block, J. P. (2023). Association Between Hypertension and Diabetes Control and COVID-19 Severity: National Patient-Centered Clinical Research Network, United States, March 2020 to February 2022. Journal of the American Heart Association, 12(21), 1–12. https://doi.org/10.1161/JAHA.122.030240

Jia, G., & Sowers, J. R. (2021). Hypertension in Diabetes: An Update of Basic Mechanisms and Clinical Disease. Hypertension, 78(5), 1197–1205. https://doi.org/10.1161/HYPERTENSIONAHA.121.17981

Klein, S. L., & Pekosz, A. (2014). Sex-based biology and the rational design of influenza vaccination strategies. Journal of Infectious Diseases, 209(SUPPL. 3). https://doi.org/10.1093/infdis/jiu066

Lim, S., Bae, J. H., Kwon, H. S., & Nauck, M. A. (2021). COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nature Reviews Endocrinology, 17(1), 11–30. https://doi.org/10.1038/s41574-020-00435-4

Mogi, M. (2022). Clinical study on angiotensin II vaccination—the first big step. Hypertension Research, 45(1), 162–163. https://doi.org/10.1038/s41440-021-00790-3

Nakagami, H., & Morishita, R. (2018). Recent advances in therapeutic vaccines to treat hypertension. Hypertension, 72(5), 1031–1036. https://doi.org/10.1161/HYPERTENSIONAHA.118.11084

Priyantini, D., Ambar, N., Prinka, S., & Hanggitriana, A. (2022). Indeks Massa Tubuh Pada Penderita Diabetes Melitus Dengan Nilai Ankle Brachial Index. Jurnal Ilmiah Keperawatan Stikes Hang Tuah Surabaya, 17(2), 144–149.

Suprapto. (2021). Personality Characteristics of Nursing Students with Stress Perception in Clinical Practice in the Era Covid-19 Pandemic Biomedik Dasar Keperawatan View project publish View project Suprapto Suprapto. Journal of Positive Psychology & Wellbeing, 6(1), 534–538.

Tandjungbulu, Y. F., Nuradi, N., Mawar, M., Yusril, M., Virgiawan, A. R., & Hasan, Z. A. (2022). Karakteristik Hasil Pemeriksaan Kreatinin Serum Pada Penderita Diabetes Melitus Ditinjau Dari Hasil Pemeriksaan HbA1c. Jurnal Media Analis Kesehatan, 13(2), 148. https://doi.org/10.32382/mak.v13i2.3019

Vasilev, G., Kabakchieva, P., Miteva, D., Batselova, H., & Velikova, T. (2022). Effectiveness and safety of COVID-19 vaccines in patients with diabetes as a factor for vaccine hesitancy. World Journal of Diabetes, 13(9), 738–751. https://doi.org/10.4239/wjd.v13.i9.738