Different Effects of Hylocecarus Polyrhizus and Hylocecarus Undatus Extract on Reducing Total Cholesterol of Male Rattus Norvegicus Wistar Strain
Abstract
A chronic ailment that is caused by excessive food consumption and a lack of physical activity, obesity is a condition that may be prevented. The tropical dragon fruit can control cholesterol levels, support the immune system, and give a natural colorant for culinary applications. In a true experimental research, sample with rats were fed red and white dragon fruit extracts to determine the amounts of cholesterol in their bodies. Spectrophotometry was used to determine the rats' blood lipid profiles, cholesterol levels, and body weight after they were fed a meal that was high in fat and contained duck egg yolk. For this study, extracts from red and white dragon fruits were administered to male Wistar rats to determine their effects on cholesterol levels. After fourteen days, both groups had a reduction in high cholesterol levels, with group 4 exhibiting the most significant drop in cholesterol levels. Additionally, the extracts decreased the levels of MDA while simultaneously increasing the levels of SOD. The most significant rise was seen in group 4, given white dragon fruit extract at 140 mg/200 gr BW daily. SPSS was utilized to analyze the effects of dragon fruit on blood cholesterol levels in experimental animals, employing the LSD technique and one-way ANOVA.
References
Arsyad, M., & Riska, R. (2021). Analisis Fisikokimia Selai Buah Naga Merah (Hylocereus Polyrhizus) Dengan Variasi Penambahan Kulit Buah Naga Merah. Perbal : Jurnal Pertanian Berkelanjutan, 9(3), 159–168. https://doi.org/10.30605/PERBAL.V9I3.1588
Bergin, P., Leggett, A., Cardwell, C. R., Woodside, J. V., Thakkinstian, A., Maxwell, A. P., & McKay, G. J. (2021). The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: a systematic review and meta-analysis. BMC Nephrology, 22(1), 1–10. https://doi.org/10.1186/S12882-021-02328-8/TABLES/2
Casso, F. M. J., & Farzam, K. (2022). Biochemistry, Very Low Density Lipoprotein. StatPearls.
Cherian, D., Peter, T., Narayanan, A., Madhavan, S., Achammada, S., & Vynat, G. (2019). Malondialdehyde as a marker of oxidative stress in periodontitis patients. Journal of Pharmacy And Bioallied Sciences, 11(6), 297. https://doi.org/10.4103/JPBS.JPBS_17_19
Ghozali, I. (2018). Aplikasi Analisis Multivariate dengan Program IBM SPSS 25. In Badan Penerbit Universitas Diponegoro.
Harvey, R. A., & Ferrier, D. R. (2017). Lippincott’s illustrated reviews : biochemistry. News.Ge, https://news.ge/anakliis-porti-aris-qveynis-momava.
Kamarudin, N. A., Muhamad, N., Hakimah Nik Salleh, N. N., & Tan, S. C. (2021). Impact of Solvent Selection on Phytochemical Content, Recovery of Tannin and Antioxidant Activity of Quercus Infectoria Galls. Pharmacognosy Journal, 13(5), 1195–1204. https://doi.org/10.5530/pj.2021.13.153
Kayamori, Y., Hatsuyama, H., Tsujioka, T., Nasu, M., & Katayama, Y. (1999). Endpoint Colorimetric Method for Assaying Total Cholesterol in Serum with Cholesterol Dehydrogenase. Clinical Chemistry, 45(12), 2158–2163. https://doi.org/10.1093/CLINCHEM/45.12.2158
Kenneth, R., & Feingold, M. D. (2021). Introduction to Lipids and Lipoproteins. Comprehensive Free Online Endocrinology Book Endotex, 1–42.
Koliaki, C., Liatis, S., & Kokkinos, A. (2019). Obesity and cardiovascular disease: revisiting an old relationship. Metabolism, 92, 98–107. https://doi.org/10.1016/J.METABOL.2018.10.011
Kristanto, D. (2014). Berkebun Buah Naga. Penebar Swadaya Grup.
Lee, Y., & Siddiqui, W. J. (2019). Cholesterol Levels. StatPearls [Internet].
Marrelli, M., Conforti, F., Araniti, F., & Statti, G. A. (2016). Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity. Molecules 2016, Vol. 21, Page 1404, 21(10), 1404. https://doi.org/10.3390/MOLECULES21101404
Naomi, R., Teoh, S. H., Embong, H., Balan, S. S., Othman, F., Bahari, H., & Yazid, M. D. (2023). The Role of Oxidative Stress and Inflammation in Obesity and Its Impact on Cognitive Impairments—A Narrative Review. Antioxidants 2023, Vol. 12, Page 1071, 12(5), 1071. https://doi.org/10.3390/ANTIOX12051071
Notoatmodjo, S. (2022). Metodologi Penelitian Kesehatan (3rd ed.). Jakarta: Rineka Cipta.
Piché, M. E., Tchernof, A., & Després, J. P. (2020). Obesity Phenotypes, Diabetes, and Cardiovascular Diseases. Circulation Research, 126(11), 1477–1500. https://doi.org/10.1161/CIRCRESAHA.120.316101
Quispe, R., Elshazly, M. B., Zhao, D., Toth, P. P., Puri, R., Virani, S. S., Blumenthal, R. S., Martin, S. S., Jones, S. R., & Michos, E. D. (2020). Total cholesterol/HDL-cholesterol ratio discordance with LDL-cholesterol and non-HDL-cholesterol and incidence of atherosclerotic cardiovascular disease in primary prevention: The ARIC study. European Journal of Preventive Cardiology, 27(15), 1597–1605. https://doi.org/10.1177/2047487319862401
Rubino, F., Puhl, R. M., Cummings, D. E., Eckel, R. H., Ryan, D. H., Mechanick, J. I., Nadglowski, J., Ramos Salas, X., Schauer, P. R., Twenefour, D., Apovian, C. M., Aronne, L. J., Batterham, R. L., Berthoud, H. R., Boza, C., Busetto, L., Dicker, D., De Groot, M., Eisenberg, D., … Dixon, J. B. (2020). Joint international consensus statement for ending stigma of obesity. Nature Medicine 2020 26:4, 26(4), 485–497. https://doi.org/10.1038/s41591-020-0803-x
Rusip, G., Ilyas, S., Lister, I. N. E., Ginting, C. N., & Mukti, I. (2022). The effect of ingestion of red dragon fruit extract on levels of malondialdehyde and superoxide dismutase after strenuous exercise in rats (Rattus norvegicus). F1000Research, 10, 1061. https://doi.org/10.12688/f1000research.54254.3
Smith, J. B., & Mangkoewidjojo, S. (1988). Pemeliharaan, Pembiakan dan Penggunaan Hewan Percobaan Di Daerah Tropis. Jakarta: UI-Press.
Suwarno, B., & Nugroho, A. (2023). Kumpulan Variabel-Variabel Penelitian Manajemen Pemasaran (Definisi & Artikel Publikasi) (1st ed.). Bogor: Halaman Moeka Publishing.
Ullah, A., Munir, S., Badshah, S. L., Khan, N., Ghani, L., Poulson, B. G., Emwas, A. H., & Jaremko, M. (2020). Important Flavonoids and Their Role as a Therapeutic Agent. Molecules 2020, Vol. 25, Page 5243, 25(22), 5243. https://doi.org/10.3390/MOLECULES25225243
UNICEF Indonesia. (2019). Analisis Lanskap Kelebihan Berat Badan dan Obesitas di Indonesia.
Vona, R., Pallotta, L., Cappelletti, M., Severi, C., & Matarrese, P. (2021). The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders. Antioxidants 2021, Vol. 10, Page 201, 10(2), 201. https://doi.org/10.3390/ANTIOX10020201
Wijitra Liaotrakoon. (2013). Characterization of dragon fruit (Hylocereus spp.) components with valorization potential Wijitra Liaotrakoon. https://doi.org/10.599
Witosari, N., & Widyastuti, N. (2014). Pengaruh Pemberian Jus Daun Ubi Jalar (Ipomoea Batatas (L.) Lam) Terhadap Kadar Kolesterol Total Tikus Wistar Jantan (Rattus Norvegicus) Yang Diberi Pakan Tinggi Lemak.
Wolfensohn, S., & Lloyd, M. (2013). Handbook of laboratory animal management and welfare. John Wiley & Sons.
Y.A. Barku, V. (2019). Wound Healing: Contributions from Plant Secondary Metabolite Antioxidants. In Wound Healing - Current Perspectives. IntechOpen. https://doi.org/10.5772/intechopen.81208
Younus, H. (2018). Therapeutic potentials of superoxide dismutase. International Journal of Health Sciences, 12(3), 88.
Copyright (c) 2024 Journal La Medihealtico
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
