The Impact of Oral Maternal Colostrum Administration on the Immune System of Premature Babies
Abstract
In children under five years of age, premature complications are now the second leading cause of death. Colostrum has important benefits in promoting the maturity of premature infants' organ functions and preventing infections. Preterm infants are recommended to be given colostrum orally and pharyngeally as early as possible after birth to provide immune protective effects for their bodies. However, the sucking and swallowing functions of preterm infants are often not optimal, partly due to comorbidities, which poses a significant challenge. As a result, the immune system of preterm infants is often low. This literature review aimed to evaluate the effect of oropharyngeal colostrum feeding through subgroup analysis based on complications. Descriptive research was conducted in April-June 2024 using the literature review method with PRISMA guidelines for RCTs. Literature sources were obtained from Pubmed (MEDLINE), Science Direct, Google Scholar, and Cochrane with a publication limit of the last ten years (2014-2023). Of the 1,657 results, 13 articles met the criteria. A total of 1,451 preterm infants were included in the 13 RCT studies. Results showed a lower incidence of late-onset sepsis and Necrotizing Enterocolitis (NEC) in the group that received oropharyngeal colostrum. The administration of oropharyngeal colostrum was shown to have a positive impact on the development and defense of the immune system of preterm infants, reduce health problems such as sepsis and NEC, accelerate the recovery of birth weight, and reduce the incidence of mortality.
References
Abd-Elgawad, M., Eldegla, H., Khashaba, M., & Nasef, N. (2020). Oropharyngeal Administration of Mother’s Milk Prior to Gavage Feeding in Preterm Infants: A Pilot Randomized Control Trial. Journal of Parenteral and Enteral Nutrition, 44(1), 92–104. https://doi.org/10.1002/jpen.1601
Aggarwal, R., Plakkal, N., & Bhat, V. (2021). Does oropharyngeal administration of colostrum reduce morbidity and mortality in very preterm infants? A randomised parallel-group controlled trial. Journal of Paediatrics and Child Health, 57(9), 1467–1472. https://doi.org/10.1111/jpc.15529
Aziz, M. A., Faye, B., Al-Eknah, M., & Musaad, A. (2016). Modeling lactation curve of Saudi camels using the linear and non-linear forms of the incomplete Gamma function. Small Ruminant Research, 137, 40-46. https://doi.org/10.1016/j.smallrumres.2016.03.001
Blencowe, H., Cousens, S., Oestergaard, M. Z., Chou, D., Moller, A. B., Narwal, R., Adler, A., Vera Garcia, C., Rohde, S., Say, L., & Lawn, J. E. (2012). National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: A systematic analysis and implications. The Lancet, 379(9832), 2162–2172. https://doi.org/10.1016/S0140-6736(12)60820-4
Chen, L. L., Liu, J., Mu, X. H., Zhang, X. Y., Yang, C. Z., Xiong, X. Y., & Wang, M. Q. (2022). Oropharyngeal administration of mother’s own milk influences levels of salivary sIgA in preterm infants fed by gastric tube. Scientific Reports, 12(1), 1–8. https://doi.org/10.1038/s41598-022-06243-2
da Cruz Martins, C., de Santana Xavier Ramos, M., Viana Cardoso Amaral, M., Santos Passos Costa, J., Souza Cerqueira, E., de Oliveira Vieira, T., ... & Oliveira Vieira, G. (2020). Colostrum oropharyngeal immunotherapy for very low birth weight preterm infants: protocol of an intervention study. BMC pediatrics, 20, 1-11. https://doi.org/10.1186/s12887-020-02266-8
Ferreira, D. M. L. M., Oliveira, A. M. M., De Leves, D. V., De Bem, É. B., Fatureto, G. G., Navarro, N. F., Afonso, N. G., Santiago, F. M., Mineo, J. R., Sopelete, M. C., Martinez, F. E., Bernardino Neto, M., & Abdallah, V. O. S. (2019). Randomized Controlled Trial of Oropharyngeal Colostrum Administration in Very-low-birth-weight Preterm Infants. Journal of Pediatric Gastroenterology and Nutrition, 69(1), 126–130. https://doi.org/10.1097/MPG.0000000000002356
Fu, Z. Y., Huang, C., Lei, L., Chen, L. C., Wei, L. J., Zhou, J., Tao, M., Quan, M. T., & Huang, Y. (2023). The effect of oropharyngeal colostrum administration on the clinical outcomes of premature infants: A meta-analysis. International Journal of Nursing Studies, 144. https://doi.org/10.1016/j.ijnurstu.2023.104527
Garg, B. D., Balasubramanian, H., Kabra, N. S., & Bansal, A. (2018). Effect of oropharyngeal colostrum therapy in the prevention of necrotising enterocolitis among very low birthweight neonates: A meta-analysis of randomised controlled trials. Journal of Human Nutrition and Dietetics, 31(5), 612–624. https://doi.org/10.1111/jhn.12585
Gila-Diaz, A., Arribas, S. M., Algara, A., Martín-Cabrejas, M. A., Pablo, Á. L. L. de, Pipaón, M. S. de, & Ramiro-Cortijo, D. (2019). A review of bioactive factors in human breastmilk: A focus on prematurity. Nutrients, 11(6), 1–23. https://doi.org/10.3390/nu11061307
Glass, K. M., Greecher, C. P., & Doheny, K. K. (2017). Oropharyngeal Administration of Colostrum Increases Salivary Secretory IgA Levels in Very Low-Birth-Weight Infants. American Journal of Perinatology, 34(14), 1389–1395. https://doi.org/10.1055/s-0037-1603655
Gomes, R. D., Anaya, K., Galdino, A. B., Oliveira, J. P., Gama, M. A., Medeiros, C. A., ... & Rangel, A. H. (2021). Bovine colostrum: A source of bioactive compounds for prevention and treatment of gastrointestinal disorders. NFS Journal, 25, 1-11. https://doi.org/10.1016/j.nfs.2021.10.001
Jain, S., Kumar, M., Tripathi, S., & Singh, S. N. (2022). Oral Application of Mother’s Own Milk for Prevention of Late Onset Sepsis in Preterm Very Low Birth Weight Neonates: A Randomized Controlled Trial. Breastfeeding Medicine, 17(1), 59–64. https://doi.org/10.1089/bfm.2021.0184
Lee, J., Kim, H. S., Jung, Y. H., Choi, K. Y., Shin, S. H., Kim, E. K., & Choi, J. H. (2015). Oropharyngeal colostrum administration in extremely premature infants: An RCT. Pediatrics, 135(2), e357–e366. https://doi.org/10.1542/peds.2014-2004
Masi, A. C., & Stewart, C. J. (2019). The role of the preterm intestinal microbiome in sepsis and necrotising enterocolitis. Early Human Development, 138, 104854. https://doi.org/10.1016/j.earlhumdev.2019.104854
Mose, A., Dheresa, M., Mengistie, B., Wassihun, B., & Abebe, H. (2021). Colostrum avoidance practice and associated factors among mothers of children aged less than six months in Bure District, Amhara Region, North West, Ethiopia: A community-based cross-sectional study. PLoS ONE, 16(1), 1–11. https://doi.org/10.1371/journal.pone.0245233
OuYang, X., Yang, C. Y., Xiu, W. L., Hu, Y. H., Mei, S. S., & Lin, Q. (2021). Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational age ≤ 32 weeks: a pilot single-center randomized controlled trial. International Breastfeeding Journal, 16(1), 1–15. https://doi.org/10.1186/s13006-021-00408-x
Panchal, H., Athalye-Jape, G., & Patole, S. (2019). Oropharyngeal colostrum for preterm infants: a systematic review and meta-analysis. Advances in nutrition, 10(6), 1152-1162. https://doi.org/10.1093/advances/nmz033
Pietrzak, B., Tomela, K., Olejnik-Schmidt, A., Mackiewicz, A., & Schmidt, M. (2020). Secretory IgA in intestinal mucosal secretions as an adaptive barrier against microbial cells. International journal of molecular sciences, 21(23), 9254. https://doi.org/10.3390/ijms21239254
Pinto, F., Fernandes, E., Virella, D., Abrantes, A., & Neto, M. T. (2019). Born preterm: a public health issue. Portuguese Journal of Public Health, 37(1), 38-49. https://doi.org/10.1159/000497249
Sharma, D., Kaur, A., Farahbakhsh, N., & Agarwal, S. (2020). Role of oropharyngeal administration of colostrum in very low birth weight infants for reducing necrotizing enterocolitis: a randomized controlled trial. American journal of perinatology, 37(07), 716-721. https://doi.org/10.1055/s-0039-1688817
Slouha, E., Anderson, Z. S., Mansa, N., Ankrah, N., Kalloo, A. E., & Rakesh Gorantla, V. (2023). Colostrum and Preterm Babies: A Systematic. https://doi.org/10.7759/cureus.42021
Sriraman, N. K. (2017). The Nuts and Bolts of Breastfeeding: Anatomy and Physiology of Lactation. Current Problems in Pediatric and Adolescent Health Care, 47(12), 305–310. https://doi.org/10.1016/j.cppeds.2017.10.001
Sudeep, K. C., Kumar, J., Ray, S., Dutta, S., Aggarwal, R., & Kumar, P. (2022). Oral Application of Colostrum and Mother’s Own Milk in Preterm Infants—A Randomized, Controlled Trial. Indian Journal of Pediatrics, 89(6), 579–586. https://doi.org/10.1007/s12098-021-03982-4
Superti, F. (2020). Lactoferrin from bovine milk: a protective companion for life. Nutrients, 12(9), 2562. https://doi.org/10.3390/nu12092562
Taha, Z., Ali Hassan, A., Wikkeling-Scott, L., & Papandreou, D. (2020). Factors associated with preterm birth and low birth weight in Abu Dhabi, the United Arab Emirates. International journal of environmental research and public health, 17(4), 1382. https://doi.org/10.3390/ijerph17041382
Turula, H., & Wobus, C. E. (2018). The role of the polymeric immunoglobulin receptor and secretory immunoglobulins during mucosal infection and immunity. Viruses, 10(5), 237. https://doi.org/10.3390/v10050237
Wilson, C. B., & Ogra, P. L. (2011). Human Milk. In Infectious Diseases of the Fetus and Newborn Infant (7th ed., Vol. 240, Issue 1988). Elsevier Inc. https://doi.org/10.1016/B978-1-4160-6400-8.00005-5
Zhang, Y., Ji, F., Hu, X., … Y. C.-P. C. C., & 2017, undefined. (n.d.). Oropharyngeal colostrum administration in very low birth weight infants: a randomized controlled trial. Journals.Lww.Com. https://doi.org/10.1097/PCC.0000000000001221
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