Effect Jamblang Stem Barks, Mangosteen Peel, and Cinnamon to Blood Sugar Levels
Diabetes mellitus ranks seventh as the most deadly disease with a prevalence of 1.9% and is dominated by type 2 diabetes mellitus with 95%. A solution is needed to overcome this problem, one of which is by utilizing jamblang stem barks, cinnamon, and mangosteen peel which are packaged in a popular product, namely steeping tea bags. This research aimed to determine the effect and potential biodiversity of extracts of jamblang stem barks, cinnamon and mangosteen peel as an antidiabetic drug in the form of infusion in rats induced by alloxan. This research used one-factor completely randomized design (CRD) with a linear model. Data were analyzed by One Way ANOVA and Post-hoc Tukey. The sample used was male mice aged 2-3 months with a body weight of ± 20 grams. The sample consisted of 25 individuals and divided into 5 groups. group I (control), group II (alloxan induction + jamblang stem barks extract, cinnamon, and mangosteen peel 1.35 grams / 200gBB), group III (alloxan induction + mangosteen peel 1.35 grams / 200gBB), group IV (alloxan induction + wood sweet 1.35 gram / 200gBB), group V (alloxan induction + jamblang stem barks 1.35 gram / 200gBB). Day 21, the amount of increase in blood sugar levels was observed and assessed based on the results of the tools used. The results showed that the infusion of jamblang stem barks, cinnamon and mangosteen peel had a significant effect on reducing blood sugar so that it could prevent type 2 diabetes mellitus.
Alam, M.R., Rahman, A., Moniruzzaman, M., Kadir, F., Haque, M., Alvi, M.,&Ratan, M. (2012). Evaluation of Antidiabetic Phytochemicals in Syzygium cumini(L.) Skeels. Journal of Applied Pharmaceutical Science,2(10), 94-98.
Ambarsari, W. 2013. Test of the Effect of Ethanol Extract 70% of Jamblang Stem Bark (Syzygium cumini) on Aloxan-Induced Reduction in Blood Glucose Levels of White Rats (Rattus norvegicus). Skripsi. Faculty of Medicine, University of Muhammadiyah Surakarta.
Artha, I., Bhargah, A., Dharmawan, N., Pande, U., Triyana, K., & Mahariski, P. (2019). High Level of Individual Lipid Profile and Lipid Ratio as a Predictive Marker of Poor Glycemic Control in Type-2 Diabetes Mellitus. Journal Vascular Health Risk Manage, 15(1), 149-157.
Babu, P., Liu, & Gilbertc. (2013). Recent Avances in Understanding The Anti-Diabetic Actions of Dietary Flavonoids. Journal of Nutritional Biochemistry. 24(11): 1777-1789.
Bonner-Weir, S., Li, W., Yahalom, L., Guo, L., Weir, G., & Sharma. A. (2010). ß-Cell Growth and Regeneration: Replication is Only Part of the Story.Journal Diabetes. 59(4): 2340-2348.
Fatimah, R. N. (2015). Diabetes Melitus Tipe 2. Journal Majority, 4(5), 93-101.
International Diabetes Federation. (2017). IDF Diabetes Atlas Eight Edition. Brussel: International Diabetes Federation.
Katiyar, D., Singh, V., & Ali, M. (2016). Recent Advances in Pharmacological Potential of Syzygium cumini: A Review. Advances in Applied Science Research, 7(3), 1-12.
Kusumaningtyas, I., Fajariyah, S., & Utami, E. (2014). The Effect of Cinnamon (Cinnamomum burmanii) Steeping on the Structure of the Pancreas of Mice (Mus musculus) Diabetic Balb-C Strain. Jurnal Ilmu Dasar, 15(2), 69-73.
Maligan, J., Chairunnisa, F., & Wulan, S. (2018). Role of Xanthon Mangosteen Rind (Garcinia mangostana L.) as an Antihyperglycemic Agent. Jurnal Ilmu Pangan dan Hasil Pertanian, 2(2), 99-106.
Mursyida, E., & Wati, H. M. (2021). Aktivitas Antibakteri Ekstrak Kayu Manis (Cinnamomum burmannii) Terhadap Pertumbuhan Escherichia coli. Jurnal Farmakologi, 8(2), 87-91.
Negi, J. S., Bisht, V., Singh, P., Rawat, M., & Joshi, G. (2013). Naturally Occurring Xanthones: Chemistry and Biology. Journal of Applied Chemistry, 13(1), 1-9.
Prabakaran, K., & Shanmugavel, G. (2018). Antidiabetic Activity and Phytochemical Constituents of Syzygium cumini Seeds in Puducherry Region, South India. International Journal of Pharmacognosy and Phytochemical Research, 9(7), 985-989.
Sariga, C.D., Shakila, R., & Khotai, S. (2015). Isolation, Characterization and Quantification of Bergenin from Syzygium cumini stem bark. International Research Journal of Pharmacy, 6(2), 108-110.
Soelistijo, S., Novida, H., Rudijanto, A., Soewondo, P., Suastika, K., & Manaf, A. (2015). Consensus on the Management and Prevention of Type 2 Diabetes Mellitus in Indonesia 2015. Jakarta: Perkumpulan Endokrinologi Indonesia.
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